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Ralph Tiedt Selected Research

capmatinib

12/2020A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment.
1/2020A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma.
1/2019Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation.
1/2019A phase II study of the efficacy and safety of the MET inhibitor capmatinib (INC280) in patients with advanced hepatocellular carcinoma.

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Ralph Tiedt Research Topics

Disease

12Neoplasms (Cancer)
04/2020 - 08/2011
5Leukemia
03/2020 - 08/2016
3Myeloproliferative Disorders (Myeloproliferative Disorder)
02/2009 - 04/2005
3Thrombocytosis (Thrombocythemia)
02/2009 - 04/2008
3Thrombosis (Thrombus)
12/2007 - 04/2005
2Breast Neoplasms (Breast Cancer)
01/2021 - 10/2018
2Hemorrhage
11/2007 - 04/2005
1Skin Ulcer
01/2021
1Wounds and Injuries (Trauma)
01/2021
1Colorectal Neoplasms (Colorectal Cancer)
12/2020
1Multiple Myeloma
03/2020
1Fatigue
01/2020
1Glioblastoma (Glioblastoma Multiforme)
01/2020
1Headache (Headaches)
01/2020
1Nausea
01/2020
1Constipation
01/2020
1Splenomegaly
01/2019
1Hepatocellular Carcinoma (Hepatoma)
01/2019
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2019
1Cholangiocarcinoma
01/2017
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2017
1Neoplasm Metastasis (Metastasis)
01/2017
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
02/2012
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
08/2011
1Dizziness (Lightheadedness)
05/2008
1Syncope (Fainting)
05/2008
1Thrombocytopenia (Thrombopenia)
11/2007
1Sepsis (Septicemia)
11/2005
1Fibrosis (Cirrhosis)
04/2005
1Primary Myelofibrosis (Myelosclerosis)
04/2005
1Essential Thrombocythemia
04/2005
1Polycythemia Vera
04/2005

Drug/Important Bio-Agent (IBA)

7Proteins (Proteins, Gene)FDA Link
01/2020 - 02/2009
4capmatinibIBA
12/2020 - 01/2019
3ribociclibIBA
01/2021 - 10/2018
3Cyclin-Dependent Kinases (cdk Proteins)IBA
04/2020 - 10/2018
3Histone MethyltransferasesIBA
03/2017 - 08/2016
2NVP-BKM120IBA
01/2021 - 01/2020
2ErbB Receptors (EGF Receptor)IBA
12/2020 - 10/2018
2Lysine (L-Lysine)FDA Link
03/2020 - 08/2016
2MethyltransferasesIBA
03/2020 - 08/2016
2Hormones (Hormone)IBA
01/2020 - 10/2018
2Biomarkers (Surrogate Marker)IBA
01/2019 - 01/2019
2LigandsIBA
01/2019 - 10/2012
2Phosphotransferases (Kinase)IBA
10/2012 - 08/2011
2Janus Kinase 2IBA
02/2012 - 11/2005
1AlpelisibIBA
01/2021
1Fulvestrant (Faslodex)FDA Link
01/2021
1Cetuximab (Erbitux)FDA Link
12/2020
1Monoclonal AntibodiesIBA
12/2020
1Pharmaceutical PreparationsIBA
03/2020
1Histones (Histone)IBA
03/2020
1TensinsIBA
01/2020
1Chloroquine (Aralen)FDA LinkGeneric
01/2020
1Antidepressive Agents (Antidepressants)IBA
01/2020
1Lipase (Acid Lipase)FDA Link
01/2020
1Anti-Bacterial Agents (Antibiotics)IBA
01/2020
1Alanine Transaminase (SGPT)IBA
01/2020
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2020
1Azithromycin (Zithromax)FDA LinkGeneric
01/2020
1Transcription Factors (Transcription Factor)IBA
01/2020
1Lu 28-179 (Siramesine)IBA
01/2020
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2019
1Janus Kinase InhibitorsIBA
01/2019
1Tyrosine Kinase InhibitorsIBA
01/2019
1Aromatase InhibitorsIBA
10/2018
1Messenger RNA (mRNA)IBA
07/2017
1siremadlinIBA
01/2017
1Circulating Tumor DNAIBA
01/2017
1Tumor Suppressor Protein p53IBA
01/2017
1Cell-Free Nucleic AcidsIBA
01/2017
1Proto-Oncogene Proteins c-mdm2IBA
01/2017
1Tumor Suppressor Protein p14ARF (p14ARF)IBA
01/2017
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
01/2017
1infigratinibIBA
01/2017
1tyrosine receptor (receptor, tyrosine)IBA
10/2012
1Cytokine Receptors (Cytokine Receptor)IBA
02/2012
1Tyrosine (L-Tyrosine)FDA Link
08/2011
1Imatinib Mesylate (Gleevec)FDA Link
08/2011
1Protein Isoforms (Isoforms)IBA
02/2009
14,5,6,7- tetrahydroisoxazolo(4,5- c)pyridin- 3- ol (THPO)IBA
05/2008
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
05/2008
1Thrombopoietin (c-mpl Ligand)IBA
05/2008
1InterferonsIBA
04/2008
1Hemoglobins (Hemoglobin)IBA
04/2008
1IntegrinsIBA
12/2007
1TalinIBA
12/2007
1CollagenIBA
11/2007
1Myosins (Myosin)IBA
11/2007
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
11/2007
1Hemostatics (Antihemorrhagics)IBA
11/2007
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
11/2005
1DNA (Deoxyribonucleic Acid)IBA
04/2005

Therapy/Procedure

7Therapeutics
01/2021 - 04/2005